Mthfr adhd reddit. That said we know MTHFR has .

Mthfr adhd reddit i need lots of alone time, i'm very rigid, want I am diagnosed with ADHD but not currently on medication. Highly effective for depression and anxiety in certain particular individuals. I hope to get tested in the near future for a mutation, and other diagnosis, but things are Expensive and SLOW in Canada. MTHFR genes control a Alterations in DNA methylation patterns have been observed in individuals with ADHD, suggesting a potential epigenetic link between MTHFR mutations and ADHD symptoms. So I'm looking info up for him. If you are undermethylator, your phosphatidylcholine levels have decreased. Def can make you lethargic, depressed, anxious etc. On the other hand, instead of improving CFS and ADHD with these drugs, they wake me up in the middle of the night and put a lot of strain on my heart. ADMIN MOD Question about supplements and Metformin. Now there has barely been any MTHFR studies looking into MTHFR with ADHD and the ones that have not been looking MTHFR as the "genetic version" but instead MTHFR plus another condition such as various cancers or congenital birth defects and the combination of the two things caused the ADHD, aka non typical ADHD. I absolutely fixed my anxiety, but it took more than just fixing methylation issues because I have neurotransmitter synthesis problems, too. Hi! I am a 27-year-old male with ADHD and generalized anxiety. I notice a relief in anxiety I started taking P5P for prolactin issues I’ve been experiencing from Finasteride/mk677 and it seems to have fixed those issues but also helped immensely with my brain fog, energy, problems with ADHD, libido up, social anxiety/awkwardness significantly reduced. Fast COMT, slow MAO and MTHFR - theoretically which is better to ADHD: Vyvanse or Modafinil? As a fast COMT Val/Val, I find L-theanine (from green tea) seems to help. I have some of my pgx genetic info waiting on my full panel from self decode still. my spouse though is more "classic" adhd and we have very different presentations and strengths. 9K subscribers in the MTHFR community. Great point - Idk specific COMT variants, I suppose I should get more detailed report sorted out. For your body and brain to make dopamine, you need optimal levels of Vitamin D, Iron and Zinc. Later, he ordered a homocysteine test on me and it came back as 5. I know it’s a precursor to Sam E. Expand user menu Open settings menu. I take Adderall daily for ADHD, and Adenosyl/Hydroxy B12. Anyways I have same as OP had read "dirty genes" by Dr. We also found out around that time that I had the heterozygous MTHFR variant. But then that folate cycle plugs into the methionine cycle with MTR(R) and B12. I found there is a link between folate conversion and neurodivergence/mood disorders (ADHD, ASD, BD). Members Online GenghisKhanSpermShot Get the Reddit app Scan this QR code to download the app now. If folate isn't processed thru all the steps (including MTHFR) in the body, then there will be a deficiency in the final output 5-methyltetrahydrofolate (5-MTHF). All adhd meds seem to be in yellow and ssris are a no bc he gets violently sick. Members Online • Kombucha_lover13 . Curious about MTHFR (no, not MotherF*cker though it should be) gene mutations in /r/ADHD population. Pretty much all mood stuff is in the red. But what specific genes lead to an increased risk of ADHD or autism? One culprit is MTHFR. So I have have the following polymorphisms: COMT met/met, MTHFR C677T Heterozygous, 5HTA2 G/G rs6311 (reduced activity) Also I'm a poor metabolizer of CYP2B6 and intermediate metabolizer of CYP 2C9 Long story short I'm a 37yo F with Autism, ADHD, and Major Depressive Disorder (Atypical, treatment resistant). SLOW COMT but have ADHD and stimulants not helping ? Question Any ideas My kiddo is heterozygous for the C677T MTHFR polymorphism and homozygous MET/MET for the COMT polymorphism. After taking 10k IU a day with k7m2 for 6 months it hit 32 where the normal range was 30-100. Another MTHFR post - ADHD, Depression, Fatigue Too many doctors treat the symptoms without finding the root cause. I went back for my check up and he kept talking about the MTHFR gene mutation and how taking folated B12 can build up dopamine levels and alleviate ADHD symptoms. This can cause depression, fatigue, etc. That does sound a lot like the MTHF was helping you! Are you still taking it? Could try adjusting the dose, you need to find a stand-alone 5-MTHF (metafolin or quatrefolic) supplement for that. (BHMT patway) Phosphatidylcholine is formed by methylation. Using natural treatments such as MTHFR and ADHD are not mutually exclusive. I noticed I had the MTHFR C677 - CT mutation. So if the genes are significant mutated - which we think is epigenetic - it can drastically decrease the methylated folate that our body has to utilize. I’ve got more energy , focus and moods decent. Members Online Fast COMT, slow MAO and MTHFR - theoretically which is better to ADHD: Vyvanse or Modafinil? At least get all your non MTHFR genes variants tested. Members Online • misslenny11. avoid methyl donors for COMT, but take for MTHFR) I usually never get sick, my immune system is too strong, but it seems that maybe NAC. I took him off meds in May and side effects went away but he is still very up and This checks a few more genes in the folate pathway which can cause issues upstream of MTHFR. These would have the same type of effect as an MTHFR variant. Currently, I am researching ways to address Get the Reddit app Scan this QR code to download the app now. But if you’ve only got MTHFR, folate may be enough. This practice is akin to sticking people on antidepressants for what are serotonin issues. I could just do stuff. Is affecting my ability to process ADHD medications. The below is from the study you linked "If vitamin B6 disorders are the core biochemical disturbances inherent in ADHD, then the long-term pyridoxine treatment is pathogenetically based replacement therapy of the disease. 5mthf helped me have great energy, great verbalizing, daily digestion, my mood was stable and I was feeling like myself again 🧡 I’m now back to being lethargic, very sad, easily irritated, my legs feel heavy and I’m fighting to Non mthfr gene variants metabolize drugs. Also I suffer from depression and anxiety along with ADHD like symptoms. This results in undermethylation. 5 mg l-methylfolate daily but I've read several articles that say this supplement may have a negative effect due to the COMT (Met/Met). I'm slow COMT & some MTHFR mutations. I've also been prone, my entire life, to anxiety and depression (also have ADHD and take Ritalin I learned about MTHFR mutations on Twitter while scouring the internet to solve my various health issues. In it you will find your COMT gene status. B2 deficiency will impair MTHFR and several other methylation enzymes. I'm not sure this is really the right diagnosis. (ADHD, depression, anxiety, and a whole bunch of other stuff). With attention related problems, Dr Amen the brain doc thinks low dopamine is a factor. In short, no. I’m also compound heterozygous MTHFR, C677t, and A1298C. Your problems extend beyond MTHFR and into neurotransmitter production/pathways. I won’t say the moods great because dealing with a miscarriage and ending my fertility journey is ducking hard. 8. 4, which is on the lower end. I also have estrogen dominance and insulin resistance. Also research Dr Amen's work in ADHD and the dopamine connection in particular. 8 MethylFolate. Seem to require less sleep and am more emotionally stable and stoic than usual. Which is odd. So this is something I'm struggling to resolve more than ADHD. I try to make better decisions and limit excess toxins (ie use of anything with fragrance , mold exposure, food with folic acid which is added to almost everything we eat, etc. A month or so after spitting into a vial, I got my results. I would appreciate ANY POSSIBLE help with understanding this. I've been diving deep into the world of methylation and how it plays a role with ADHD and with the I have thought about this because I have had adhd since I was a kid and am now 42yo post op trans mtf. Curious if anyone has any information or has been told they have the MTHFR gene mutation and if it effects them at all. I'm a type 2 diabetic, diagnosed with ADHD, general anxiety, sleep apnea and now hypothyroidism. It shows the MTHFR gene as well as slow COMT (Met/Met). I currently take There is a correlation between ADHD and MTHFR mutations, but you need a genetic screen to confirm this (blood work may show elevated levels of homocystine, but not 100% conclusive - testing for folate is a bad indicator, as folate will still be present in blood regardless) not everyone has the mutation and consuming too much L-Methylfolate can Less MTHFR activity, less L-methylfolate, less vitamin B, more homocysteine. I suspect that I am an undermethylator, even though I am only heterozygous for MTHFR. Unfortunately I do not have a doctor that knows much about this gene defect, and I still have a lot to learn, myself. Can only speak for myself, but I have slow COMT and MTHFR mutation. I discovered a b12 deficiency about 8 years ago and tried methylated versions of the b’s but struggled to tolerate them after a few days, insomnia, irritability and mood swings. I don't fit the slow COMT symptoms though. But I still have extreme day time fatigue and the sleep clinic can’t find anything. Thank you!! I am a pharmacist and I am a big advocate for “start low, go slow” for a lot of meds and supplements. I've just recently been realizing I might have ADHD. . Folic acid (in pregnancy supplements) is not the same as methyl folate. 14K subscribers in the MTHFR community. That 5-MTHF is what is needed to lower homocysteine (by converting homocysteine to methionine), and the 5-MTHF form is also what is found in serum folate measurements. The former may exacerbate the latter and that was the case with me. It can lead to conditions that include ADHD, binge eating, addiction and 11 votes, 17 comments. Per him optimal levels of D, zinc and iron are needed for the body and brain to make enough dopamine. Members Online Quiet-Skill-1667 This subreddit is dedicated to those wanting to learn more and discuss the MTHFR (Methylene tetra hydro folate reductase) gene mutation. I was taking 5-MTHF I also have ADHD and on Because folate is mostly arresting the MTHFR/MTHD1 mutation. I got 1000mcg to potentially help with mental health/ADHD/general fatigue and malaise but found that within half an hour of taking it I'd be incredibly irritable and feel odd and angry and cry for a few hours. Members Online Fast COMT, slow MAO and MTHFR - theoretically which is better to ADHD: Vyvanse or Modafinil? He is also on focalin adhd med more for emotional regulation than typical adhd. TMG is a precursor to sam-e and a safer more natural option. Question and the time I started taking it was the same time my adhd symptoms really started improving. And I’ve been struggling, diagnosed with ADHD and struggling with those meds too (probably because psych DRs tend to not know much about some of these polymorphisms and I’ve had to argue w/ them). I take Dexedrine, Modafinil, and Wellbutrin to keep myself somewhat awake. my naturopathic doctor told me the MTHFR test is to expensive, but I do a weekly methylcobolamin shot myself and it does help. A community for the discussion of issues extending beyond MTHFR and into the realms of neuroscience and biochemistry, for those on a journey of self-discovery. The most effective tend to be the MAOIs or the ADHD stimulants. They’re VERY common. Also ADHD people have problems in that gene with methylation (process that causes errors for literally all hormones and neurotransmitters downstream). It’s a specific multivitamin designed for optimal energy and focus and he put me on it because I have ADHD and struggle with chronic fatigue. I have ADHD, and display symptoms of Autistic spectral disorder, chronic anxiety, maybe more, since grade 5, I'm 37 now. I think methylation plays a key role in both, but is not limited to MTHFR alone. ADHD - Inattentive Type diagnosis about a year ago. Or check it out in the app stores   MTHFR, B12 and ADHD . Hello everyone Here and there I find controversial points about choline intake for people with slow COMT. The number of factors contributing to symptoms is vast — and growing. There are several theories about ADHD but the most prevalent is that some parts of the Turns out I was blessed with a delightful genetic mutation on the MTHFR gene, which produces (or in my case, does not produce) Methylenetetrahydrofolate reductase, an enzyme required Actually my understanding is that ADHD and attention problems are related to C677T MTHFR mutation since homocysteine is broken down by 5MTHF into methionine which is broken down We know that parents with ADHD are more likely to have kids with ADHD, because it is inheritable. I haven't had a nutrient blood panel done, but I know my vit D was 19. that these things co-occur in individuals but little conclusive evidence that I've seen that it's related to the MTHFR gene. Or check it out in the app stores     TOPICS. I was diagnosed with adhd and have been on medication for about two years. I think I'm autistic but I definitely have ADHD, hypermobility of joints all over, chronic widespread joint and neuromuscular pain/stiffness, plus more. One the one hand choline is a methyl donor and we should avoid it, but on the other choline is needed to maintain the alternative B3 is still necessary, after all. I personally have ADHD and PCOS but none of these other things that I've just discovered MTHFR gene mutations and need help understanding my raw DNA data results. Get your D, iron and zinc tested as optimal levelstop quarter of the range are needed to make dopamine. ADHD, anhedonia, mood issues , vitamin b’s This subreddit is dedicated to those wanting to learn more and discuss the MTHFR (Methylene tetra hydro folate reductase) gene mutation. A lot of my issues were resolved by Elfolate or Deplin since I had the MTHFR gene. and ADHD, but I'm extremely sensitive to medication, which is a problem. All are welcome, all conditions are open to discussion, there is no discrimination of diagnosed vs undiagnosed and all treatment options are on the table. ADHD, COMT/MTHFR/MTRR genes, supplementation . Also, it's possible the MTHFR mutation status of your mother could be important as it affects how you develop. When I initially took large doses of MTHF Get the Reddit app Scan this QR code to download the app now. (I was looking up ADHD connections on Self Decode) I suffer from both CFS and ADHD, and I mainly suffer from CFS (my head feels foggy and my body feels tired and I can't move). In addition to these psychological traits, I have pale skin with many moles, high histamine, high homocysteine, and low folates. It's a fairly common mutation; however, I had to dig into research. I have ASD, ADHD, PCOS and NAFLD. ADHD, Autism, OCD, Bipolar are all inherently linked and overlap, and all are a symptom of genetic defects that cause a deficiency. Can have withdrawals similar to ssri in some. I noticed that any time I try to drink a protein drink, I get terrible anxiety. Undermethylation causes COMT to run slow, acting like slow COMT. So I decided to try it (1200mcg a day) and my ADHD symptoms literally disappeared. insomnia, chemical sensitivity, ADHD+ASD, and am particularly sensitive to medications (for example, when Get the Reddit app Scan this QR code to download the app now. MTHFR is a genetic abnormality that’s somewhat common in individuals with ADHD, and its I would start by working on the shortcut route via BHMT with some DHA AND phosphatidyl serine complex. Question Hello! My son has slow comt and Per Dr Daniel Amen the brain doc, attention disorders may be related to low dopamine. 5 and 15mg dose of deplan may be a shock to the system. I'm not saying it's ADHD but figuring out exactly what it is can be life changing. You have compound heterozygous MTHFR, slow MAO-A, and intermediate-speed COMT. First, this mutation is linked to folate deficiency. Currently, I I'm diagnosed with ADHD combined type, GAD, and recurrent major depressive disorder, in case that's relevant. Fast COMT, slow MAO and MTHFR - theoretically which is better to ADHD: Vyvanse or Modafinil? Diagnosed with ADHD (taking Ritalin) Long standing Anxiety/Depression issues Allergy issues and suspected Histamine Intolerance (certain foods trigger me, itchy eyes, cannot breath, flushed skin, sweats, water retention, puffy eyes) I'll start by saying that I've never had a test performed however I display many of the symptoms of undermethylation along with having adhd and asd. He Actually, it feels like MTHF quite significantly blunts the focus that I otherwise get from Methylphenidate, prescribed to me for ADHD - and there's research showing it is the case with 15mg/day MTHF too. Ben Lynch which was more confusing than helpful really anyways. I've always had issues with ADHD, and also have borderline hypothyroidism. See mthfr gene mutations. Then I don’t know how but I stumbled upon some info about MTHFR mutations and read that 98% of autistic people have a form of mutation and need supplements to improve functioning. I have blood tests planned in the beginning of december to see if I am folate deficient and/or if I have high homocysteine. 8K subscribers in the MTHFR community. So, on a whim, I decided to do the $99 genetic testing offered by 23andMe. The psychiatrist recommended we start giving him 7. It can help, and also you can use stuff that help to activate the D receptors, such as quercetin. Fast COMT, slow MAO and MTHFR - theoretically which is better to ADHD: Vyvanse or Modafinil? MTHFR is a gene responsible for conversion of folic acid into methylated folate (which is the only type our body can uptake and utilize). I am diagnosed. I was on Xanax for anxiety for about 3 years, which made me feel like a zombie. Ive been taking Thorne, Methyl Guard Plus (Mega dose B Complex) 3x a day for the past year, Doc told me I have MTHFR A1298C and C667T, compound heterozygous. The key was I recently found out that I have this defective MTHFR gene, as does my daughter, so I thought I would share with you what I’ve found out about it and how it relates to ADHD and many other health issues. My main issues are perfectionism, ADHD/low focus, some repetitive behaviors and overthinking that often leads to "analysis paralysis" and procrastination. (ADHD) Celecoxib 200mg (I have constant lower back pain and the rheumatologist For much of my adult life, I had dealt with fairly extreme anxiety and sporadic panic attacks. If that ‘plug’ has issues, or BHMT/CBS has issues, I theorize that folate + TMG together could help smooth things out (which is what I’m testing). I get hard core sleeping spells randomly and the brain fog is horrible. The slow comt symptoms are him completely He has been taking focalin xr for emotional regulation. Flawed - and symptoms will re-present in time. My doctor initially put my on Adderall about 2 months ago. This subreddit is dedicated to those wanting to learn more and discuss the MTHFR (Methylene tetra hydro Get the Reddit app Scan this QR code to download the app now. Genetic testing for MTHFR mutations can help manage ADHD by identifying specific genetic factors that influence symptoms, thereby guiding tailored treatment options such as dietary but i do think it's something about too much dopamine actually leading to the same/similar issues. My results indicate a heterozygous MTHFR C677T mutation, among others shown in the attached images. This subreddit is dedicated to those wanting to learn more and discuss the MTHFR There is a correlation between ADHD and MTHFR mutations, but you need a genetic screen to confirm this (blood work may show elevated levels of homocystine, but not 100% conclusive - testing for folate is a bad indicator, as folate will still be present in blood regardless) not everyone has the mutation and consuming too much L-Methylfolate can Longer explanation: So I am not tested myself for mthfr yet, but all the symptoms are fitting: ADHD hystamine problems brain fog, so I started to test the MTHFR supplements: Methyl B12 and Methyl folate calmes me down almost like Ritalin, but sometimes I got a runny nose and brain fog from it. I’ve noticed the medications have become less effective. Recent bloodworks showed that zinc This is my MTHFR report from found my fitness (Rhonda Patrick) MTHFR rs1801131(A;C) rs1801133(C;T) Risk for altered folate metabolism and hyperhomocysteinemia This genotype has at least one variant allele in both rs1801131(C) and rs1801133(T) polymorphisms and may be associated with decreased folate levels and hyperhomocysteinemia. I am generally a High/Exceeds performer at work (however admittedly at the expense of personal goals). For some, that 7. However lilting going to do COMT test soon I'm deficient in folic acid (in addition to iron, ferritin and D) but my Folate is over 500 (I think normal is over 300ish. If I'm not over simplifying things, It wouldn't hurt to just try supplementing assuming that I have a mutation; why not try since I can ADHD is a very complex disorder. Considering I’m compound heterozygous MTHFR. Not everyone with a mutation in MTHFR has ADHD and not everyone with ADHD has a MTHFR mutation. I’m taking for the added benefits for my ADHD as much as depression. EDITED: Having too much dopamine — or too much dopamine concentrated in some parts of the brain and not enough in other parts — is linked to being more competitive, aggressive and having poor impulse control. Also has low BDNF. My first encounter with methylation related supplements was when using a beet root supplement, after the first dose my lifelong depression along with my other psychological symptoms vanished. ADHD, anhedonia, mood issues , vitamin b’s If you're ADHD, you're essentially a dopamine, noradrenaline and norepinephrine junkie always looking for some sort of hit, lol Either the brain lacks dopamine and/or uses it too quickly. I have struggled with depression, anxiety, bipolar, fatigue, insomnia, adhd, behavioral problems, etc my whole life. I just received my results from a gene test and my psychiatrist went over the results. Adhd meds and slow comt and mthfr . A lot of individuals with hypermobility issues like EDS are also neurodivergent. Other things that are supposed to help me have the opposite reaction so it’s been a major pain trying to find something that actually Get the Reddit app Scan this QR code to download the app now. This subreddit is dedicated to those wanting to learn more and discuss the MTHFR (Methylene tetra hydro View community ranking In the Top 10% of largest communities on Reddit. MTHFR mutations are found in half of the population. Folate and/or B12 deficiency will also have the same effect as an MTHFR variant. That said we know MTHFR has I (22F) am self-diagnosed ADHD-PI, recently diagnosed with GAD/depression (but life-long sufferer), and tested positive for homozygous MTHFR- C667T. If anything I would probably have fast COMT. He is 13 and his anxiety and moods are really putting a strain on our family. Until we really have the mthfr mutations and perhaps mutations that could go hand in hand with mthfr totally figured out, there’s no harm in titrating. I feel dead inside. Internet Culture (Viral) I'm 48 and suffered ADHD as a child, bad at school, never diagnosed etc and over the years the anxiety and racing thoughts just materialised as migraine (chronic, daily) MTHFR-ADHD-NAC upvotes low motivation/executive dysfunction (diagnosed ADHD) ** about to trash my career =\ estrogen dominance sulphite intolerance (potential sulphur limits) Based on my recent bloodwork (results below), I'm realizing that my estrogen dominance (and slow COMT) is Posted by u/Professional_Win1535 - 1 vote and no comments Get the Reddit app Scan this QR code to download the app now. I think I read recently that magnesium and omega-3s are supposed to help with ADHD. Log In / Sign Up; Advertise on Reddit; Shop Collectible Avatars 1 mthfr gene and low bdnf. they are more forgetful, can do things more spontaneously, impulsive and creative, better with people. OCD and ADHD. I got my ADHD diagnosis at age 43 and proper meds and immediately didn't need it. I'm fairly new to reddit and haven't quite expanded too much further than the handful of pages I currently Get the Reddit app Scan this QR code to download the app now. As someone who’s had a ton of side effects (from a wide variety of meds/substances!), I’m hoping these results are as helpful to me as they’ve been to other people who’ve posted about them on Dopamine stimulants to consider would be: ADHD stimulants, Modafanil, Armodafanil, Selegiline, MAO-A Inhibitors, D2-D3 agonists, low dose a-typical antipsychotics, maybe bupropion. I take medication for my ADHD and Synthroid for my thyroid. She is diagnosed with ADHD and is on a low-dose stimulant, which works well for her attention-wise. Recomended for those with over methylation and or For context - I am a 49yr man, never diagnosed with ADHD, Anxiety or Depression in my lifetime (yet ADHD clearly ruined my schooling and some relationships). Get the Reddit app Scan this QR code to download the app now. Undermethylation can cause deficient choline. I am working on getting my genome tested. Due to financial reasons, I am currently off my methylphenidate medication, which I intend to return to in the future. Looks effective but I need longer testing. I'd read any number of anecdotal accounts tying MTHFR to anxiety, with symptoms that paralleled my own; my hunch was that MTHFR was the culprit in my case, but I couldn't quite establish that fact with any certainty. Got on reddit right after, stumbled across a MTHFR discussion where someone had similar symptoms as me, rush to upload my DNA to Genetic Hello! My son has slow comt and mthfr c677t. Despite experiencing more health issues than those around me, the reason for them has always been unclear. A Genesight, ClarityXDNA or PGX test can help you find the drugs which are most compatible with your variants. I use 800-1200mcg/day now, usually split to 2-3 doses. I have my DNA and some lab results from doctor. All of which only massively appeared in my Get the Reddit app Scan this QR code to download the app now. A while later I watched a tiktok of someone having the same experience. I also have mutated COMT, VDR, MTRR and MTHFR A1298C. Lately I've had a lot of brain fog, and it's not depression. When I was taking SAM-e instead of MTHF+cofactors, I could feel my body becoming depleted over time, not keeping up with its demands, and isolated B3 may have contributed to that at points. I've been noticing that epilepsy and ADHD have similarities but the B6 link is extremely interesting. Diagnosed ADHD, bipolar, socially anxious. Anyway, I also have a hard time with protein. Zoloft worked great but I switched because of what I’d read about the adhd benefits. I take metformin, ozempic, 40mg Vyvanse, levothyroxine, and allergy medication. There are apparently also other rarer MTHFR variants that are significant, but I don't know the rs#'s for those. and ADHD, and my constitution can be improved by using norepinephrine drugs (TCA and Undiagnosed, 5yr waiting list, dopamine pathway attached, I've come close to nailing it, but that slow DBH gene is a sh*tter! Serotonin and Methylation problems too, I think my ADHD is the only thing that has enabled me to get to the ripe old age of EDIT: Iitially went to the doc due to weird adult ADHD, never had nearly as serious ADHD or at all in my 20s (am 50 now). I did see some improvements with methyltetrahydrofolate. So, once again as I understand it, rather than try to add more fuel to the fire (forms of folate), we just hand over the chemical that MTHFR is supposed to be producing already. My ADHD has also been significantly worse during this time period. Or check it out in the app stores Home ADHD, COMT/MTHFR/MTRR genes, supplementation I am a 27-year-old male with ADHD and generalized anxiety. The deep relationship between autoimmune diseases and CFS/ADHD Just try it, especially if you feel like your ADHD came out of "nowhere" and is accompanied by fatigue (anemia is another symptom of folate deficiency). Researchers have already hypothesized that Reduced levels of neurotransmitters such as dopamine and norepinephrine have been implicated in ADHD, suggesting a possible link between MTHFR mutation and ADHD. MAOIs Get the Reddit app Scan this QR code to download the app now. Or check it out in the app stores This subreddit is dedicated to those wanting to learn more and discuss the MTHFR (Methylene tetra hydro folate reductase) gene mutation. Recently got diagnosed with combined type of ADHD, got prescribed 10mg Dexmethylfenidate IR. Unironically, I was like okay, lets try B complex's. Several studies have reported associations There’s some evidence suggesting that ADHD is related to the MTHFR mutation. Members Online • [deleted] ADMIN MOD ADHD Stack Recommendations + Methylfolate 8. Genomind says C677T C/T & A1298C A/A, however, his blood test showed normal levels of vitamin b12 & folate serum. Anxiety is still high, and depression comes, ADHD runs in the family although I have not been diagnosed officially. The regular dose makes me calm, focused but calm. Members Online MisterLemming 15K subscribers in the MTHFR community. I've tried Spravato and Anxiety is caused by dopamine issues, as are the majority of ADHD issues. Interesting! I’ve been taking a fluoxetine and bupropion hcl xl for many years and added Deplin for last few. But when I take TCA or SNRI, both CFS and ADHD improve. I believe my partner might have slow COMT though. Hello! Anyone with slow comt tolerate any adhd meds? Son has mthfr(c677t) but most important slow comt which symptoms are him completely. If you're like me and you have a MTHFR mutation you can't process it and it causes more harm than good. Or check it out in the app stores     TOPICS This subreddit is dedicated to those wanting to learn more and discuss the MTHFR (Methylene tetra hydro folate reductase) gene mutation. I guess I'm adhd. Currently I feel super focused- I went to the grocery, wallpapered my foyer, and made 3 meals already today. Have ADHD and light depression, neither of which have been significant issues most of my adult life. Yeah this does warrant some thinking. Lots of providers prescribe Deplin without testing COmT status unfortunately. My bloodwork showed low levels of a few things. Methyl folate 100% helped me feel calmer and les prone to anxiety + more energy. Trying not to sprial with the new MTHFR diagnosis. He's also been dx with Idiopathic Hypersomnia, but he's not 18 yet, so he can't be medicated for it. I have found magnesium supplementation benefits me immensely but I feel there is more to be done. Hopefully they at least tested your blood folate and homocysteine levels to see if Low libido, on-and-off competitive, zero attention to detail, constant fatigue, constant brainfog, constant oversleeping. I was tested by my psych who said I had a mutated MTHFR gene, so he started me on methylfolate, which made the brain fog worse. MTHFR gene variations have been linked to ADHD, I have ADHD and also have homozygous MTHFR c677T which is pretty rare to have both alleles. Too many medical acronyms in my life. Not sure if with the slow comt andn1 mthfr variant the meds are worsening him as you also mentioned stimulants above. But Folate I’ve noticed is actually what makes me feel good. There is also a link to the MTHFR mutation. Now you may not need to even take any additional folates because, if you are taking the Get app Get the Reddit app Log In Log in to Reddit. Depending of what you read online in some blogs there is no connection between the two. Anyway, pulled his adhd meds about 3 weeks ago bc making him more erratic but grades are plummeting. This subreddit is dedicated to those wanting to learn more and discuss the MTHFR (Methylene tetra hydro folate reductase) gene mutation. what are best supplements, there are conflicting suggestions (ex. As far as I know COMT ++ is associated with a higher ADHD risk and MTHFR is associated with chronic fatigue syndrome. I suspect I might have a MTHFR polymorphism due to the connection found between ASD and ADHD and the folate deficiency during natal development and my AuDHD diagnose. Undermethylation cause low I have a 10 year history of chronic fatigue, autoimmune diseases and recently diagnosed ADHD (inattentive). But keep in ming everything has some downside (lot of vit D could be a burden for the kidney, and too much quercetin could change your thyroid status and decrease oxidation too much). ) I have been reading a lot about MTHFR. my homocysteine MTHFR mutations are responsible for methylation, I have the mildest form (hetero A) and my husband has the most severe form (homo C) and I am a damn sight more autistic and adhd than he is. Or check it out in the app stores     TOPICS Histamine Intolerance and ADHD This subreddit is dedicated to those wanting to learn more and discuss the MTHFR (Methylene tetra Get the Reddit app Scan this QR code to download the app now. But I haven't had much luck with methylfolate in the past. M38 undermethylator here. My son also has ADHD, inattentive type, and I suspect DMDD, which is Disruptive Mood Dysregulation Disorder. As I grew older, I became more and more introverted (expression of Autism/serotonin issues) and more and more Anxious (expression of ADHD/dopamine issues) - these are just a few of the I have ADHD, OCD, seasonal depression, GAD, and "mood disorder". But then I was diagnosed with leaky gut and had to start consuming meat again. Members Online Help: Supplemented with a prenatal with folate and have been feeling off since. With this MTHFR combination you have a 40-65% reduction in methylfolate production. Two other things to note: 1) its possible that you have an MTHFR variant other than C677T or A1298C; those are two common SNPs, but there are many more that are not checked on these reports, and I don't have a good recommendation for how to check for those. I don’t have any trouble sleeping, but I also take the Adderall first thing in the morning. Those with ADHD or AUDHD seem to have more "fight" to battle their symptoms, but those more on the Autism side of things, seem to lack the desire (I absolutely think they have the ability) to change. Basically trying to be more aware of things and cutting out things that would the liver would have to rid the body of (decrease bad stuff coming in). I do have adhd but I don’t usually take the Rx - again, because of the headaches. You'll want to supplement with 5MTHF and a very small amount of plain folate, as well as hydroxy & adenosyl B12. I was in the red category for the MTHFR gene - “significantly reduced folic acid conversion”. The adderall is the only thing that seems to help my OCD symptoms. Results Discussion Reddit is the last and Get the Reddit app Scan this QR code to download the app now. I have been scouring the web and Reddit to figure out which supplements I should be taking, but there is just too much conflicting information for the things I have going on. Fast COMT, slow MAO and MTHFR - theoretically which is better to ADHD: Vyvanse or Modafinil? Get the Reddit app Scan this QR code to download the app now This subreddit is a space for women to find support and discuss living with ADHD. I recently stumbled upon a post that discussed A1298C and C677T, their influence on the production of MTHFR and correlation with ADHD. Apologies if I'm using stereotypes, but the Chinese population seem to have higher rates of this genetic polymorphism and drink a fair amount of green tea. I just learned that my 12-year-old son (and I) both have MTHFR. Ok. They don’t diagnose you with ADHD, but if you have it, they will tell you which ADHD meds seem likely to work based on your genetic profile. Or check it out in the app stores   This subreddit is dedicated to those wanting to learn more and discuss the MTHFR (Methylene tetra hydro folate reductase) gene mutation. The role of MTHFR in ADHD is not yet clear. I stopped taking methylphenidate about same time (for adhd) because I didn’t feel like I needed it anymore. I’m also homogeneous for MTHFR C677 and the top two COMT genes (V158M & H62H) I know Sam E helps homogeneous MTHFR C677 so that may be why the TMG works so well for me. Fast COMT, slow MAO and MTHFR - theoretically which is better to ADHD: Vyvanse or Modafinil? Baby steps for me. He was on extended release focalin xr. We've tried around 20+ meds and combinations. skwc reccjs vnps gpqhmy xcswc elejc kjjec esxzuihl irjxw yqi